This DNA looping mechanism is often referred to as the "trombone model" of replication since the DNA loop grows and dissolves repeatedly, like the motion of a trombone slide 6, 10The physical and genetic evidence supporting dimerization of DNA polymerase III fits nicely with a structural model for replication This is a socalled inchworm, or trombone, model of DNA replication (Figure 3) As indicated in the model, a dimer at the growing fork would allow coupling of rates of synthesis on the leading and lagging strandsFor example, the bacterial replisome utilizes clamps and clamp loaders to coordinate the actions required of the trombone model of lagging strand synthesis made famous by Bruce Alberts All cells contain clamps and clamp loaders and this review summarizes their structure and function
Trombone Model Of Dna Replication In Hindi Youtube
